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Select Publications

Borck, P.C., Boyle, I., Jankovic, K. et al. SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO.

Nature 638, 1104–1111 (2025). https://doi.org/10.1038/s41586-024-08509-3

Gu, J., Iyer, A., Wesley, B. et al. Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.

Nat Biotechnol 43, 1101–1115 (2025). https://doi.org/10.1038/s41587-024-02386-x

van Wietmarschen, N., Sridharan, S., Nathan, W.J. et al. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

Nature 586, 292–298 (2020). https://doi.org/10.1038/s41586-020-2769-8

Chan, E.M., Shibue, T., McFarland, J.M. et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.

Nature 568, 551–556 (2019). https://doi.org/10.1038/s41586-019-1102-x

Edmond M. Chan, Yash Chhabra, Karen O. Dixon, Adam D. Durbin, Anniina Färkkilä, Anand D. Jeyasekharan, Zuzana Keckesova, John R. Prensner, Elvin Wagenblast, Stephanie Z. Xie, Di Zhao; Insights on Future Directions in Cancer Research from the 2025 AACR NextGen Stars.

Cancer Discov 1 April 2025; 15 (4): 678–684. https://doi.org/10.1158/2159-8290.CD-25-0239

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